butabarbital, calcium/magnesium/potassium/sodium oxybates. Either boosts effects of the opposite by pharmacodynamic synergism. Contraindicated. Coadministration with Alcoholic beverages or sedative hypnotics are contraindicated as a result of additive CNS depression.
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The dose of the medicine will likely be various for various sufferers. Comply with your health care provider's orders or even the directions around the label. The next information and facts features only the average doses of the medication. When your dose differs, will not change it Except if your health care provider informs you to do so.
These agents should really only be mixed if alternate remedy solutions are insufficient. If put together, Restrict the dosages and period of each drug. Contemplate therapy modification
buprenorphine subdermal implant and butabarbital both of those increase sedation. Stay away from or Use Alternate Drug. Limit use to individuals for whom different therapy solutions are insufficient
Selected medicines shouldn't be employed at or across the read more time of eating food stuff or eating selected sorts of foodstuff because interactions may possibly arise.
butabarbital will lessen the level or outcome of diltiazem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
butabarbital increases effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers may well maximize metabolism of ifosfamide to its metabolite. Keep track of for enhanced outcomes/toxicities if coupled with CYP2B6 inducers.
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Even though selected medicines shouldn't be employed jointly whatsoever, in other conditions two various medicines can be used together even if an conversation may manifest. In these situations, your medical professional should want to alter the dose, or other safeguards might be essential.
butabarbital will lessen the level or influence of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Solid CYP3A4 inducers might lower midostaurin concentrations causing reduced efficacy.
butabarbital will lessen the level or outcome of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
butabarbital will minimize the level or impact of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.